The Journal of Supercritical Fluids-26 August 2019 藤黄酸

郑重说明:

您值得信赖的中药成分及标准合作伙伴满足您研发和工业化需求

产品关键词：香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚茯苓新酸B 去甲异波尔定

guanyuwomen关于德思特

联系方式

服务热线：

028-8500-3950

公司传真：	028-85589956
公司邮箱：	sales@tcmlmt.com
公司网址：	www.028desite.com
公司地址：	四川省成都市温江区海科路西段128号5栋

发表文献展示

当前位置:首页关于德思特 > 发表文献展示 >

时间：2020-09-03 浏览次数：分享到：

Solubility measurement and RESOLV-assisted nanonization of gambogic acid in supercritical carbon dioxide for cancer therapy
期刊名：The Journal of Supercritical Fluids
文献编号：DOI 10.1016/j.supflu.2019.04.008
文献地址：https://www.sciencedirect.com/science/article/pii/S0896844619300658?via%3Dihub
发表日期：26 August 2019

Abstract
Despite the captivating interest for its potential anticancer efficacy against multiple types of cancer and ability to overcome multidrug resistance, the practical application of gambogic acid (GA) has been hampered by its poor water solubility. Herein, the fabrication of nanosized GA particles (251.2 nm ± 85.6 nm) using eco-friendly supercritical fluid (SCF)-assisted rapid expansion of a supercritical solution into a liquid solvent (RESOLV) process was demonstrated. The equilibrium solubility of GA in supercritical carbon dioxide (SC−CO2) was initially determined at altered supercritical conditions (P: 10.0 MPa to 30.0 MPa, T: 308.15 K–328.15 K) and the obtained data points were then correlated using various density-based models including Méndez-Santiago and Teja, Bartle as well as Chrastil models. The solubility of GA in SC−CO2 was found to be between 1.63 × 10−6 and 22.62 × 10−6 in terms of GA mole fraction, and considerably good correlation agreement was obtained with all the applied models and being the lowest deviations obtained with the Méndez-Santiago and Teja model. Furthermore, the fabricated GA nanoparticles (NPs) through benign RESOLV technique, were systematically characterized. Subsequently, in vitro antiproliferation tests resulted in its augmented antitumor efficacy due to enhanced solubility of GA. Together, the results have suggested that the benign RESOLV process has successfully fabricated nanosuspensions of GA with enhanced bioavailability and antineoplastic efficacy and may have great potential in pharmaceutics.

gambogic acid was purchased from DeSiTe Biological Technology Co. Ltd. (Chengdu, China)

上一篇：Royal Society of Chemistry-12 Aug 2019 圣草次苷

下一篇：Molecules-23 July 2019 半齿泽兰素

Afrormosine CAS:550-79-8 中药对照品标准品

产品编码：DA0040产品名称：Afrormosine英文名:AfrormosineCAS登录...